KPV 10mg (10 Vials)

Overview

KPV is a synthetic tripeptide analogue of alpha-melanocyte stimulating hormone (α-MSH). In laboratory and controlled preclinical research settings, KPV is studied for its activity in inflammatory signaling, epithelial barrier behavior, and immune-response pathways. This product is supplied strictly for research use only. It is not approved or intended for human or animal use, and any discussion of biological activity refers only to preclinical or in vitro research.

Anti-Inflammatory Properties

In laboratory research, KPV is examined for its effects on inflammatory pathways and tissue-response markers in controlled experimental systems. Preclinical studies may evaluate changes in inflammatory cell infiltration, enzyme activity, and histopathological markers of tissue injury. Any references to mucosal or recovery-related endpoints are provided only for research context and do not imply therapeutic or clinical use.

Mechanistic Insights and Clinical Significance

Mechanistic investigations have explored how KPV influences inflammatory signaling pathways in controlled laboratory models. Researchers may study how localized delivery affects experimental readouts in gastrointestinal, epithelial, or immune-system models. This information is included for scientific context only and does not constitute a claim of therapeutic benefit or approved medical use.

KPV: Structure

KPV compressed 1 500×322

Amino Acid Sequence: Lys–Pro–Val

Molecular Formula: C₁₆H₃₀N₄O₄

Molecular Weight: 342.43 g/mol

PubChem CID: 125672

CAS Number: 67727-97-3

Synonyms: MSH (11-13), ACTH (11-13), α-MSH (11-13)

Source: PubChem

Why Researchers Choose KPV

In in-vitro and ex-vivo research environments, KPV is studied for its ability to influence inflammatory cytokines through interactions with the melanocortin-1 receptor (MC1R). This selective receptor engagement makes the peptide useful in controlled experiments analyzing chronic inflammatory responses, autoimmune-like model environments, dysregulated immune pathways, and cytokine-cascade markers.

Referenced Citations

Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

Pawar, Kasturi et al.

Journal of Pharmaceutical Sciences, Volume 106, Issue 7, 1814 – 1820

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

Klaus Kannengiesser, MD , Christian Maaser, MD , Jan Heidemann, MD , Andreas Luegering, MD , Matthias Ross, MD , Thomas Brzoska, PhD , Markus Bohm, MD , Thomas A. Luger, MD , Wolfram Domschke, MD , Torsten Kucharzik, MD

Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.